The ADAM19 Polyclonal Antibody (CAB10260) is a valuable tool for researchers studying ADAM19, a cell surface protein belonging to the ADAM (A Disintegrin And Metalloproteinase) family known for its role in proteolytic cleavage and shedding of cell surface proteins. This antibody, produced in rabbits, is highly specific for human samples and is validated for use in Western blot applications. ADAM19 plays a significant role in processes such as cell adhesion, migration, and signaling, making it a key player in various physiological and pathological conditions including cancer, inflammation, and cardiovascular diseases.
By detecting and analyzing ADAM19 expression in different cell types, researchers can further elucidate its function and potential as a therapeutic target.The ADAM19 Polyclonal Antibody is essential for studies in cell biology, molecular biology, and drug discovery, providing insights into the complex mechanisms regulated by ADAM19 and its implications for disease progression. Its high reactivity and specificity make it a valuable tool for researchers aiming to uncover the intricate roles of ADAM19 in health and disease.
Product Name:
ADAM19 Rabbit Polyclonal Antibody
SKU:
CAB10260
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 203-460 of human ADAM19 (NP_150377.1).
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease.
Purification Method:
Affinity purification
Gene ID:
8728
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ADAM19 antibody (CAB10260) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
