The ADAM17 Polyclonal Antibody (CAB0821) is a valuable tool for researchers studying the ADAM17 protein, a key molecule involved in cell signaling and inflammation regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ADAM17 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it particularly useful for studies in immunology and cancer research.ADAM17, also known as TNF-alpha converting enzyme, plays a crucial role in the shedding of cell surface proteins and the regulation of inflammatory processes.
Its involvement in signaling pathways and cellular responses makes it an attractive target for investigation in diseases such as cancer, inflammatory conditions, and autoimmune disorders. By understanding the function and activity of ADAM17, researchers can work towards developing novel therapies that target this protein and modulate immune responses in disease settings.
Product Name:
ADAM17 Rabbit Polyclonal Antibody
SKU:
CAB0821
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 700-824 of human ADAM17 (NP_003174.3).
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands, and plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. Additionally, this protease may play a role in viral infection through its cleavage of ACE2, the cellular receptor for SARS-CoV and SARS-CoV-2.
Purification Method:
Affinity purification
Gene ID:
6868
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ADAM17 Rabbit pAb (CAB0821) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 5s.
