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ADAM17 Rabbit Polyclonal Antibody (CAB0821)

SKU:
CAB0821
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
  • Signal Transduction Antibodies 3 Anti-ADAM17 Antibody CAB0821
  • Signal Transduction Antibodies 3 Anti-ADAM17 Antibody CAB0821
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:ADAM17 Rabbit Polyclonal Antibody
SKU:CAB0821
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 700-824 of human ADAM17 (NP_003174.3).
Sequence:KQYE SLSL FHPS NVEM LSSM DSAS VRII KPFP APQT PGRL QPAP VIPS APAA PKLD HQRM DTIQ EDPS TDSH MDED GFEK DPFP NSST AAKS FEDL TDHP VTRS EKAA SFKL QRQN RVDS KETE C
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:100 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:CSVP; TACE; NISBD; ADAM18; CD156B; NISBD1; ADAM17
Positive Sample:HepG2,Jurkat,Mouse heart,Mouse kidney
Conjugate:Unconjugated
Cellular Localization:Membrane, Single-pass type I membrane protein.
Calculated MW:93kDa
Observed MW:120kDa/100kDa

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands, and plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. Additionally, this protease may play a role in viral infection through its cleavage of ACE2, the cellular receptor for SARS-CoV and SARS-CoV-2.

Purification Method:Affinity purification
Gene ID:6868
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using ADAM17 Rabbit pAb (CAB0821) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 5s.

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