The ADAM15 Rabbit Monoclonal Antibody (CAB6813) is a cutting-edge research tool designed for the study of ADAM15, a cell surface protein involved in various physiological and pathological processes. This antibody, produced through immunization of rabbits, exhibits high specificity and sensitivity towards ADAM15 in human samples, making it a reliable tool for experiments in Western blotting and immunohistochemistry.ADAM15, a member of the ADAM (A Disintegrin And Metalloproteinase) family, is known to play a role in cell adhesion, migration, and signaling, making it a promising target for research in cancer metastasis, inflammation, and tissue remodeling.
By utilizing this antibody, researchers can accurately detect and analyze ADAM15 expression in different cell types and tissues, allowing for in-depth investigations into its functions and potential therapeutic implications.With its ability to provide valuable insights into the biological functions of ADAM15, this monoclonal antibody is an essential tool for scientists working in the fields of cell biology, cancer research, and drug development. By unraveling the mechanisms underlying ADAM15-mediated processes, researchers can pave the way for future advancements in understanding and treating various diseases.
Product Name:
ADAM15 Rabbit Monoclonal Antibody
SKU:
CAB6813
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human ADAM15 (Q13444).
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
Purification Method:
Affinity purification
Gene ID:
8751
Clone Number:
ARC1419
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of HCT116 cells, using ADAM15 Rabbit mAb (CAB6813) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
