The ADAM15 Polyclonal Antibody (CAB7756) is a powerful tool for investigating the role of ADAM15 in various biological processes. ADAM15, a member of the ADAM family of proteins, is involved in cell adhesion, migration, and signaling pathways. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for Western blot applications.With its ability to specifically bind to ADAM15 protein, this polyclonal antibody allows for the detection and analysis of ADAM15 in different cell types. Its versatility makes it an ideal reagent for researchers studying cell biology, cancer biology, and signal transduction pathways.
By understanding the function of ADAM15, researchers can uncover potential therapeutic targets for diseases such as cancer and inflammatory disorders.Overall, the ADAM15 Polyclonal Antibody (CAB7756) is a valuable asset for researchers looking to delve deeper into the mechanisms underlying ADAM15-mediated processes and pathways. Its reliability and specificity make it a crucial tool for advancing our understanding of ADAM15 biology in both normal and disease states.
Product Name:
ADAM15 Rabbit Polyclonal Antibody
SKU:
CAB7756
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 540-700 of human ADAM15 (NP_003806.3).
Cell junction, Cell projection, Cytoplasmic vesicle, Endomembrane system, Single-pass type I membrane protein, acrosome, adherens junction, cilium, flagellum, secretory vesicle.
Calculated MW:
93kDa
Observed MW:
93kDa
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
Purification Method:
Affinity purification
Gene ID:
8751
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ADAM15 antibody (CAB7756) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
