The ADAM12 Polyclonal Antibody (CAB7940) is a valuable tool for researchers studying ADAM12, a cell surface protein implicated in various biological processes, including cell adhesion, migration, and proteolysis. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the ADAM12 protein, researchers can effectively detect and analyze ADAM12 expression in a variety of cell types, making it an ideal tool for studies in cell biology and cancer research.ADAM12, a member of the ADAM (A Disintegrin And Metalloproteinase) family, plays a crucial role in tumor progression, angiogenesis, and tissue remodeling.
Its dysregulation has been associated with various cancers, making it a promising molecular target for cancer therapy. Studying the function of ADAM12 can provide valuable insights into its role in cancer development and progression, ultimately leading to the development of targeted therapies.Overall, the ADAM12 Polyclonal Antibody (CAB7940) is a valuable resource for researchers investigating the role of ADAM12 in cellular processes and cancer biology. Its high reactivity and specificity make it a reliable tool for detecting ADAM12 expression, facilitating further research into the mechanisms underlying cancer progression and potential therapeutic interventions.
Product Name:
ADAM12 Rabbit Polyclonal Antibody
SKU:
CAB7940
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 589-738 of human ADAM12 (NP_067673.2).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
100kDa
Observed MW:
100kDa
This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form.
Purification Method:
Affinity purification
Gene ID:
8038
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ADAM12 Rabbit pAb (CAB7940) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
