The AD7C-NTP Polyclonal Antibody (PACO17590) is a valuable tool for researchers studying AD7C-NTP, a protein involved in neurodegenerative diseases like Alzheimer's. This antibody, developed using rabbit antibodies, has high specificity for human samples and is ideal for use in Western blot applications. By binding to the AD7C-NTP protein, this antibody allows for the detection and analysis of AD7C-NTP in various cell types, making it a crucial tool for studies in neuroscience and neurodegenerative disorders.AD7C-NTP, also known as neuronal thread protein, has been implicated in the pathogenesis of Alzheimer's disease and other neurodegenerative conditions.
Understanding the role of AD7C-NTP in these diseases is essential for the development of novel therapies and treatment strategies. The AD7C-NTP Polyclonal Antibody provides researchers with a reliable means of investigating the function and expression of AD7C-NTP, ultimately contributing to our understanding of neurodegenerative disorders and potentially leading to the development of new therapeutic interventions.
Gel: 10%SDS-PAGE, Lysate: 60 μg, Lane: Human fetal brain tissue, Primary antibody: PACO17590(AD7C-NTP Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO17590(AD7C-NTP Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The predicted AD7CNTP protein contains 375 amino acid, and has a calculate molecular mass of about 42 kD. It is rich in serine and proline residues, has a 15-amino acid, hydrophobic leader sequence, and has 7 putative membrane-spanning regions. AD7CNTP has several phosphorylation sites, a myristoylation site, and 2 serine/threonine kinase protein domains. Northern blot analysis detected 1.4- and 0.9-kb transcripts only in adult frontal and temporal lobe. In vitro studies demonstrated that overexpression of AD7CNTP in transfected neuronal cells promoted neuritic sprouting and cell death, the 2 principal neuroanatomic lesions correlated with dementia in AD.
