The ACVR2B Polyclonal Antibody (CAB7868) is a essential tool for researchers investigating ACVR2B, a type II receptor for the TGF-beta family of signaling molecules. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it a reliable choice for Western blot experiments. By binding to the ACVR2B protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for studies in developmental biology, cell signaling, and cancer research.
ACVR2B, also known as activin receptor type IIB, plays a critical role in controlling cell growth and differentiation, making it a key player in tissue development and regeneration. Its involvement in TGF-beta signaling pathways makes it a promising target for therapeutic interventions in diseases such as cancer, fibrosis, and muscular dystrophy. Understanding the function of ACVR2B is essential for developing targeted treatments that exploit its signaling mechanisms for therapeutic benefit.
Product Name:
ACVR2B Rabbit Polyclonal Antibody
SKU:
CAB7868
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ACVR2B (NP_001097.2).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
58kDa
Observed MW:
58kDa
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
Purification Method:
Affinity purification
Gene ID:
93
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ACVR2B Rabbit pAb (CAB7868) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
