The ACVR2A Rabbit Monoclonal Antibody (CAB5237) is a valuable tool for researchers studying ACVR2A, a cell surface receptor involved in various cellular processes, including cell growth and differentiation. This antibody, developed using rabbit monoclonal technology, is highly specific to human ACVR2A samples and is suitable for use in Western blot applications.ACVR2A, also known as activin receptor type IIA, plays a key role in the TGF-beta signaling pathway and has been implicated in various diseases, including cancer and skeletal disorders. By targeting ACVR2A with this antibody, researchers can detect and analyze the protein in different cell types, providing insights into its function and potential therapeutic implications.
The ACVR2A Rabbit Monoclonal Antibody is a valuable asset for studies in cell biology, cancer research, and developmental biology, offering a high level of sensitivity and specificity for the target molecule. Its application in Western blotting allows for the easy detection of ACVR2A protein expression, enhancing our understanding of its role in disease pathogenesis and treatment strategies.
Product Name:
ACVR2A Rabbit Monoclonal Antibody
SKU:
CAB5237
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ACVR2A (P27037).
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.
Purification Method:
Affinity purification
Gene ID:
92
Clone Number:
ARC1220
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using ACVR2A Rabbit mAb (CAB5237) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
