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ACVR2A Rabbit Monoclonal Antibody (CAB5237)

SKU:
CAB5237
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:ACVR2A Rabbit Monoclonal Antibody
SKU:CAB5237
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ACVR2A (P27037).
Sequence:MGAA AKLA FAVF LISC SSGA ILGR SETQ ECLF FNAN WEKD RTNQ TGVE PCYG DKDK RRHC FATW KNIS GSIE IVKQ GCWL DDIN CYDR TDCV EKKD SPEV
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:ACVR2; ACTRII; 2A
Positive Sample:293T,A-549,SW481Mouse liver,Mouse testis,Mouse brain,Rat testis
Conjugate:Unconjugated
Cellular Localization:Membrane, Single-pass type I membrane protein.
Calculated MW:58kDa
Observed MW:80kDa

This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.

Purification Method:Affinity purification
Gene ID:92
Clone Number:ARC1220
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using ACVR2A Rabbit mAb (CAB5237) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.

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