The ACVR2A Polyclonal Antibody (CAB1981) is a valuable tool for researchers studying ACVR2A, a receptor protein belonging to the TGF-beta superfamily involved in cell signaling and regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the ACVR2A protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for studies in developmental biology, cell signaling, and cancer research.ACVR2A plays a crucial role in various cellular processes, including cell growth, differentiation, and apoptosis, making it a key target for investigating diseases such as cancer, cardiovascular disorders, and skeletal abnormalities.
Understanding the function of ACVR2A is essential for unraveling its impact on disease progression and developing potential therapeutic interventions targeting this receptor. By utilizing the ACVR2A Polyclonal Antibody, researchers can further explore the intricate mechanisms involving ACVR2A and its implications in various pathological conditions.
Product Name:
ACVR2A Rabbit Polyclonal Antibody
SKU:
CAB1981
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human ACVR2A (NP_001607.1).
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.
Purification Method:
Affinity purification
Gene ID:
92
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from A-431 cells, using ACVR2A Rabbit pAb (CAB1981) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
