ACVR2A Rabbit Polyclonal Antibody (CAB1981)
- SKU:
- CAB1981
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Product Name: | ACVR2A Rabbit Polyclonal Antibody |
| SKU: | CAB1981 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human,Mouse,Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human ACVR2A (NP_001607.1). |
| Sequence: | AILG RSET QECL FFNA NWEK DRTN QTGV EPCY GDKD KRRH CFAT WKNI SGSI EIVK QGCW LDDI NCYD RTDC VEKK DSPE VYFC CCEG NMCN EKFS YFPE MEVT QPTS NPVT PKPP YYNI L |
| Tested Applications: | WB IHC-P IF/ICC ELISA |
| Recommended Dilution: | WB,1:100 - 1:500 IHC-P,1:100 - 1:200 IF/ICC,1:50 - 1:200 |
| Synonyms: | ACVR2; ACTRII; ACVR2A |
| Positive Sample: | A-431 |
| Conjugate: | Unconjugated |
| Cellular Localization: | Membrane, Single-pass type I membrane protein. |
| Calculated MW: | 58kDa |
| Observed MW: | 58kDa |
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.
| Purification Method: | Affinity purification |
| Gene ID: | 92 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |
 | Western blot analysis of lysates from A-431 cells, using ACVR2A Rabbit pAb (CAB1981) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s. |
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