The ACVR1C Polyclonal Antibody (CAB0678) is a valuable tool for research involving ACVR1C, a receptor protein involved in cell signaling pathways, particularly in the regulation of cell growth and differentiation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples and is validated for use in Western blot applications.ACVR1C, also known as Activin receptor-like kinase 7 (ALK7), plays a crucial role in various physiological processes, including bone formation, adipogenesis, and insulin sensitivity. Dysregulation of ACVR1C has been linked to diseases such as cancer, cardiovascular disorders, and metabolic syndromes.
Therefore, studying the expression and function of ACVR1C is essential for understanding its role in these pathological conditions and developing potential therapeutic interventions.With its ability to detect and analyze ACVR1C protein in different cell types, the ACVR1C Polyclonal Antibody is an invaluable tool for researchers in the fields of molecular biology, cell signaling, and drug development. By uncovering the mechanisms underlying ACVR1C's function, this antibody can contribute to the advancement of knowledge and the discovery of novel treatment strategies for a range of diseases.
Product Name:
ACVR1C Rabbit Polyclonal Antibody
SKU:
CAB0678
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-113 of human ACVR1C (NP_660302.2).
ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).
Purification Method:
Affinity purification
Gene ID:
130399
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using ACVR1C Rabbit pAb (CAB0678) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
