The ACVR1B Polyclonal Antibody (CAB5453) is designed for research involving ACVR1B, a cell surface receptor belonging to the TGF-beta receptor family that plays a crucial role in cell signaling and development. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in Western blot and immunohistochemistry applications. It binds specifically to the ACVR1B protein, allowing for precise detection and analysis in various cell types.ACVR1B, also known as activin receptor-like kinase 4 (ALK4), is involved in various biological processes such as cell growth, differentiation, and apoptosis.
Dysregulation of ACVR1B signaling has been implicated in various diseases, including cancer, cardiovascular disorders, and developmental abnormalities. Therefore, studying the role of ACVR1B in cell signaling pathways is essential for understanding disease mechanisms and developing targeted therapies.Overall, the ACVR1B Polyclonal Antibody (CAB5453) is a valuable tool for researchers in the fields of cell biology, developmental biology, and cancer research, providing reliable and specific detection of ACVR1B protein for further investigations into its functions and potential therapeutic applications.
Product Name:
ACVR1B Rabbit Polyclonal Antibody
SKU:
CAB5453
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 24-126 of human ACVR1B (NP_004293.1).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
57kDa
Observed MW:
49kDa
This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
91
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ACVR1B antibody (CAB5453) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
