ACVR1 Rabbit Polyclonal Antibody (CAB7542)
- SKU:
- CAB7542
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | ACVR1 Rabbit Polyclonal Antibody |
SKU: | CAB7542 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-125 of human ACVR1 (NP_001096.1). |
Sequence: | SMED EKPK VNPK LYMC VCEG LSCG NEDH CEGQ QCFS SLSI NDGF HVYQ KGCF QVYE QGKM TCKT PPSP GQAV ECCQ GDWC NRNI TAQL PTKG KSFP GTQN FHLE VG |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2; ACVR1 |
Positive Sample: | NCI-H460,Mouse lung,Mouse heart |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type I membrane protein. |
Calculated MW: | 57kDa |
Observed MW: | 50kDa |
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
Purification Method: | Affinity purification |
Gene ID: | 90 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |