The ACVR1 Polyclonal Antibody (CAB7542) is a valuable tool for research involving ACVR1, a cell surface receptor that plays a key role in the TGF-beta signaling pathway. This antibody, generated in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By specifically binding to the ACVR1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for research in the fields of molecular biology and cancer research.
ACVR1, also known as activin receptor type 1, is involved in regulating various cellular processes, including cell growth, differentiation, and apoptosis. Dysregulation of the TGF-beta signaling pathway, in which ACVR1 is a critical player, has been linked to various diseases, including cancer, fibrosis, and developmental disorders. Investigating the function of ACVR1 is essential for unraveling its role in these conditions and may pave the way for developing targeted therapies in the future.
Product Name:
ACVR1 Rabbit Polyclonal Antibody
SKU:
CAB7542
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-125 of human ACVR1 (NP_001096.1).
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
Purification Method:
Affinity purification
Gene ID:
90
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ACVR1 antibody (CAB7542) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
