The ACTRT1 Polyclonal Antibody (PAC015289) is a research tool specifically designed for studying ACTRT1, a protein involved in actin regulation and cell motility. This antibody, produced in rabbits, has a high level of reactivity with human samples and has been validated for use in Western blot applications. By binding to the ACTRT1 protein, this antibody allows for the detection and analysis of ACTRT1 levels in various cell types, making it a valuable tool for researchers in the fields of cell biology and cancer research.ACTRT1, also known as actin-related protein T1, plays a crucial role in regulating the dynamics of actin filaments within cells, which is essential for processes such as cell division and cell migration.
Dysregulation of ACTRT1 has been associated with abnormalities in cell motility and can contribute to the development of cancer and other diseases. Therefore, studying the function of ACTRT1 using this antibody can provide valuable insights into the mechanisms underlying these pathological conditions and may lead to the development of novel therapeutic strategies.
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human lymphoma tissue, Primary antibody: PACO15289(ACTRT1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15289(ACTRT1 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a protein related to the cytoskeletal protein beta-actin. This protein is a major component of the calyx in the perinuclear theca of mammalian sperm heads, and it therefore likely functions in spermatid formation. This gene is intronless and is similar to a related gene located on chromosome 1. A related pseudogene has also been identified approximately 75 kb downstream of this gene on chromosome X.
Synonyms:
Actin-related protein T1
UniProt Protein Function:
ACTRT1: a protein related to the cytoskeletal protein beta-actin. This protein is a major component of the calyx in the perinuclear theca of mammalian sperm heads, and it therefore likely functions in spermatid formation. This gene is intronless and is similar to a related gene located on chromosome 1. A related pseudogene has also been identified approximately 75 kb downstream of this gene on chromosome X. [provided by RefSeq, May 2010]Protein type: CytoskeletalChromosomal Location of Human Ortholog: Xq25Cellular Component: cytoskeleton; cytoplasm
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein related to the cytoskeletal protein beta-actin. This protein is a major component of the calyx in the perinuclear theca of mammalian sperm heads, and it therefore likely functions in spermatid formation. This gene is intronless and is similar to a related gene located on chromosome 1. A related pseudogene has also been identified approximately 75 kb downstream of this gene on chromosome X. [provided by RefSeq, May 2010]
