The ACTR8 Antibody (PAC04110) is a premium quality product designed for researchers studying the ACTR8 protein, which plays a critical role in cellular functions such as DNA repair and gene transcription. This antibody is produced in rabbits and is highly specific for human samples, making it an ideal choice for studies involving protein detection and analysis.ACTR8 is a key component of the INO80 chromatin remodeling complex, which is involved in regulating gene expression and maintaining genomic stability. Dysregulation of ACTR8 has been linked to various diseases, including cancer and developmental disorders, making it a valuable target for research in these areas.
Validated for use in Western blot applications, the ACTR8 Antibody enables accurate detection of the protein in different cell types and tissues, making it a versatile tool for researchers in the fields of molecular biology, oncology, and developmental biology. By understanding the function and regulation of ACTR8, scientists can gain insights into its role in disease pathogenesis and potentially develop targeted therapies for related conditions.
Antibody Name:
ACTR8 Antibody (PACO41110)
Antibody SKU:
PACO41110
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Recombinant Human Actin-related protein 8 protein (35-175AA)
Western blot. All lanes: ACTR8 antibody at 16µg/ml. Lane 1: A549 whole cell lysate. Lane 2: HCT116 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 71, 59, 37 kDa. Observed band size: 71 kDa.
Background:
Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
ACTR8: Plays an important role in the functional organization of mitotic chromosomes. Belongs to the actin family. ARP8 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: CytoskeletalChromosomal Location of Human Ortholog: -Cellular Component: nucleusMolecular Function: protein binding; ATP bindingBiological Process: chromatin remodeling; mitosis; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cell division; DNA repair; DNA recombination
