α-Actinin-4 Rabbit Polyclonal Antibody (CAB16310)
- SKU:
- CAB16310
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | α-Actinin-4 Rabbit Polyclonal Antibody |
SKU: | CAB16310 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 570-650 of human α-Actinin-4 (NP_004915.2). |
Sequence: | HDQF KSTL PDAD RERE AILA IHKE AQRI AESN HIKL SGSN PYTT VTPQ IINS KWEK VQQL VPKR DHAL LEEQ SKQQ SNEH L |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | FSGS; FSGS1; ACTININ-4; α-Actinin-4 |
Positive Sample: | HeLa,HepG2,Raji,Mouse liver,Mouse kidney,Mouse heart,Rat lung,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cytoplasm, Nucleus. |
Calculated MW: | 105kDa |
Observed MW: | 105kDa |
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
Purification Method: | Affinity purification |
Gene ID: | 81 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |