ACTN1/ACTN2/ACTN3/ACTN4 Antibody (PACO06230)
- SKU:
- PACO06230
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
ACTN1/ACTN2/ACTN3/ACTN4 Antibody (PACO06230)
The ACTN1/ACTN2/ACTN3/ACTN4 Polyclonal Antibody (PAC06230) is a versatile tool for investigating the function of various actinin proteins in cell biology and signaling pathways. These actinin proteins are essential for maintaining cell structure, adhesion, and migration, making them key players in processes such as muscle contraction and cell adhesion.This polyclonal antibody, raised in rabbits, is highly specific to ACTN1, ACTN2, ACTN3, and ACTN4 proteins in human samples, allowing for reliable detection and analysis in Western blot applications.
By targeting these actinin isoforms, researchers can gain insights into their individual roles and interactions within different cellular processes.With the ACTN1/ACTN2/ACTN3/ACTN4 Polyclonal Antibody (PAC06230), researchers can delve deeper into the functions of actinin proteins in health and disease, leading to potential advancements in the fields of cell biology, muscle physiology, and other related areas of study.
| Antibody Name: | ACTN1/ACTN2/ACTN3/ACTN4 Antibody (PACO06230) |
| Antibody SKU: | PACO06230 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from the N-terminal region of human Actinin- α 1/2/3/4. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of Jurkat 293 HELA A549 cells using Actinin- alpha 1/2/3/4 Polyclonal Antibody. |
 | Western Blot analysis of 293 cells using Actinin-alpha 1/2/3/4 Polyclonal Antibody. |
| Synonyms: | ACTN1; α-actinin-1; α-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle α-actinin-1; ACTN2; α-actinin-2; α-actinin skeletal muscle isoform 2; F-actin cross-linking protein; ACTN3; α-actinin-3; A |
| UniProt Protein Function: | ACTN1: a cytoskeletal protein of the spectrin superfamily. An actin-binding protein with multiple roles in different cell types. A nonmuscle isoform structurally similar to the erythroid beta spectrin gene. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 14q24|14q22-q24 Cellular Component: extracellular space; cortical actin cytoskeleton; focal adhesion; extracellular region; dendritic spine; fascia adherens; pseudopodium; cytosol; Z disc; ruffle; cell projection; cytoplasm; plasma membrane; stress fiber; nucleus Molecular Function:actin filament binding; integrin binding; protein domain specific binding; protein binding; ligand-dependent nuclear receptor transcription coactivator activity; double-stranded RNA binding; calcium ion binding; vinculin binding Biological Process: regulation of apoptosis; actin crosslink formation; focal adhesion formation; platelet activation; actin filament bundle formation; extracellular matrix organization and biogenesis; platelet degranulation; negative regulation of cell motility; blood coagulation Disease: Bleeding Disorder, Platelet-type, 15 |
| NCBI Summary: | Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P12814 |
| NCBI GenInfo Identifier: | 46397817 |
| NCBI Gene ID: | 87 |
| NCBI Accession: | P12814.2 |
| UniProt Secondary Accession: | P12814,Q1HE25, Q9BTN1, B3V8S3, B4DHH3, B7TY16, |
| UniProt Related Accession: | P12814 |
| Molecular Weight: | 892 |
| NCBI Full Name: | Alpha-actinin-1 |
| NCBI Synonym Full Names: | actinin, alpha 1 |
| NCBI Official Symbol: | ACTN1Â Â |
| NCBI Official Synonym Symbols: | BDPLT15Â Â |
| NCBI Protein Information: | alpha-actinin-1; actinin 1 smooth muscle; non-muscle alpha-actinin-1; F-actin cross-linking protein; alpha-actinin cytoskeletal isoform |
| UniProt Protein Name: | Alpha-actinin-1 |
| UniProt Synonym Protein Names: | Alpha-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle alpha-actinin-1 |
| Protein Family: | Alpha-actinin |
| UniProt Gene Name: | ACTN1Â Â |
| UniProt Entry Name: | ACTN1_HUMAN |
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