The ACTL7A Polyclonal Antibody (PAC007582) is a valuable tool for researchers studying ACTL7A, a key protein involved in chromatin remodeling and gene expression regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ACTL7A protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in molecular biology and gene regulation studies.ACTL7A, also known as actin-like 7A, plays a crucial role in modulating chromatin structure and gene transcription, contributing to the regulation of cellular processes such as proliferation and differentiation.
Its involvement in epigenetic modifications makes it a target of interest for researchers studying various diseases, including cancer and developmental disorders. Understanding the function of ACTL7A can provide valuable insights into the mechanisms underlying these conditions and potentially lead to the development of novel therapeutic strategies.
AL7A: an actin-related protein (ARP). Shares significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. Its gene (ACTL7A), and a related gene, ACTL7B, are intronless. Expressed in a wide variety of adult tissues, however, its exact function is not known.Protein type: Motility/polarity/chemotaxis; CytoskeletalChromosomal Location of Human Ortholog: 9q31Cellular Component: male germ cell nucleus; Golgi apparatus; protein complex; cytoskeleton; cytoplasm; nucleusMolecular Function: structural constituent of cytoskeleton
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known. [provided by RefSeq, Jul 2008]
