The ACTL6B Polyclonal Antibody (CAB7108) is a powerful tool for researchers studying the ACTL6B protein, which plays a key role in chromatin remodeling and gene regulation. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the ACTL6B protein, this antibody allows for precise detection and analysis in a variety of cell types, making it ideal for studies in molecular biology and cancer research.ACTL6B is a critical component of chromatin remodeling complexes, influencing gene expression and cellular processes such as DNA repair and replication.
Dysregulation of ACTL6B has been linked to a variety of diseases, including cancer, developmental disorders, and neurological conditions. By understanding the function of ACTL6B, researchers can gain valuable insights into disease mechanisms and potential therapeutic targets.Overall, the ACTL6B Polyclonal Antibody (CAB7108) is a valuable tool for researchers investigating the role of ACTL6B in cellular functions and disease processes. Its high specificity and sensitivity make it an essential reagent for studies aiming to unravel the complex mechanisms of gene regulation and chromatin dynamics.
Product Name:
ACTL6B Rabbit Polyclonal Antibody
SKU:
CAB7108
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ACTL6B (NP_057272.1).
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
51412
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ACTL6B Rabbit pAb (CAB7108) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 40s.
