Active Caspase-3 Rabbit Monoclonal Antibody (CAB11021)
- SKU:
- CAB11021
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | Active Caspase-3 Rabbit Monoclonal Antibody |
SKU: | CAB11021 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CASP3 (P42574). |
Sequence: | MENT ENSV DSKS IKNL EPKI IHGS ESMD SGIS LDNS YKMD YPEM GLCI IINN KNFH KSTG MTSR SGTD VDAA NLRE TFRN LKYE VRNK NDLT REEI VELM |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | CPP32; SCA-1; CPP32B; Active Caspase-3 |
Positive Sample: | Jurkat+Staurosporine |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 32kDa |
Observed MW: | 17kDa |
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
Purification Method: | Affinity purification |
Gene ID: | 836 |
Clone Number: | ARC0185 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |