ACTG1 Antibody (PACO07580)
- SKU:
- PACO07580
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
ACTG1 Antibody (PACO07580)
The ACTG1 Polyclonal Antibody (PACO07580) is a valuable tool for researchers studying ACTG1, a crucial protein involved in cytoskeletal dynamics and cell motility. This antibody, raised in rabbits, exhibits high specificity and reactivity towards ACTG1 in human samples, making it an ideal choice for Western blot applications. By binding to ACTG1, this antibody enables accurate detection and analysis in various cell types, providing valuable insights into processes such as cell migration, cell division, and cell shape maintenance.
ACTG1 is a key component of the actin cytoskeleton, playing a vital role in cell structure and function. Dysregulation of ACTG1 has been linked to various diseases, including developmental disorders and cancer. Understanding the functions and regulation of ACTG1 is essential for unraveling the underlying mechanisms of these conditions and developing targeted treatments. The ACTG1 Polyclonal Antibody is a valuable tool for researchers looking to delve deeper into the complex roles of ACTG1 in health and disease.
| Antibody Name: | ACTG1 Antibody (PACO07580) |
| Antibody SKU: | PACO07580 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human ACTG1 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | actin, γ 1;ACTG1;ACT;ACTG;DFNA20;DFNA26 ; |
| UniProt Protein Function: | ACTG1: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Belongs to the actin family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 17q25 Cellular Component: filamentous actin; extracellular space; cytoskeleton; myofibril; membrane; plasma membrane; nucleus; cytosol Molecular Function:identical protein binding; protein binding; structural constituent of cytoskeleton; ubiquitin protein ligase binding; ATP binding Biological Process: axon guidance; retinal homeostasis; intercellular junction assembly and maintenance; ephrin receptor signaling pathway; innate immune response; sarcomere organization; cell motility; vascular endothelial growth factor receptor signaling pathway Disease: Baraitser-winter Syndrome 2; Deafness, Autosomal Dominant 20 |
| NCBI Summary: | Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in non-muscle cells. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011] |
| UniProt Code: | P63261 |
| NCBI GenInfo Identifier: | 54036678 |
| NCBI Gene ID: | 71 |
| NCBI Accession: | P63261.1 |
| UniProt Secondary Accession: | P63261,P02571, P14104, P99022, Q5U032, Q96E67, A8K7C2 |
| UniProt Related Accession: | P63261 |
| Molecular Weight: | 375 |
| NCBI Full Name: | Actin, cytoplasmic 2 |
| NCBI Synonym Full Names: | actin, gamma 1 |
| NCBI Official Symbol: | ACTG1Â Â |
| NCBI Official Synonym Symbols: | ACT; ACTG; BRWS2; DFNA20; DFNA26; HEL-176Â Â |
| NCBI Protein Information: | actin, cytoplasmic 2; cytoskeletal gamma-actin; epididymis luminal protein 176 |
| UniProt Protein Name: | Actin, cytoplasmic 2 |
| UniProt Synonym Protein Names: | Gamma-actinActin, cytoplasmic 2, N-terminally processed |
| Protein Family: | Actin |
| UniProt Gene Name: | ACTG1Â Â |
| UniProt Entry Name: | ACTG_HUMAN |
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