The ACTA2 Polyclonal Antibody (CAB7248) is a versatile tool for researchers studying ACTA2, a key protein involved in smooth muscle contraction and cell migration. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it a reliable tool for Western blot applications. By specifically targeting the ACTA2 protein, this antibody allows for the detection and analysis of ACTA2 in various cell types, making it well-suited for research in the fields of cell biology and cardiovascular disease.ACTA2, also known as alpha-smooth muscle actin, plays a crucial role in cell movement and contraction, making it a significant player in many physiological processes such as wound healing and vascular function.
Dysregulation of ACTA2 has been linked to diseases such as atherosclerosis, fibrosis, and hypertension, highlighting the importance of studying this protein in various pathological conditions. By understanding the function of ACTA2, researchers can develop targeted therapies to mitigate the impact of these diseases on human health.
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, and Moyamoya disease, as well as multisystemic smooth muscle dysfunction syndrome.
Purification Method:
Affinity purification
Gene ID:
59
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse heart, using α-Smooth Muscle Actin (ACTA2) Rabbit pAb (CAB7248) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
