The ACSS2 Polyclonal Antibody (CAB13596) is specifically designed for research involving ACSS2, an enzyme involved in the metabolism of acetate, a key metabolite in cellular processes. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in applications such as Western blot and immunohistochemistry.ACSS2 plays a critical role in cancer metabolism, promoting cell growth and survival by facilitating the utilization of acetate as an energy source. Its upregulation has been associated with poor prognosis in various cancer types, making it a promising target for cancer therapy research.
The ACSS2 Polyclonal Antibody enables the detection and analysis of ACSS2 expression in different cell types, providing valuable insights for cancer biology studies and drug development.Understanding the function and regulation of ACSS2 can lead to the development of novel therapeutic approaches for cancer treatment, targeting the metabolic vulnerabilities of cancer cells. The ACSS2 Polyclonal Antibody is a valuable tool for researchers investigating the role of ACSS2 in cancer metabolism and exploring its potential as a therapeutic target.
Product Name:
ACSS2 Rabbit Polyclonal Antibody
SKU:
CAB13596
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 462-701 of human ACSS2 (NP_061147.1).
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
55902
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ACSS2 antibody (CAB13596) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
