The ACSL6 Polyclonal Antibody (CAB7965) is a valuable tool for researchers studying ACSL6, an enzyme involved in fatty acid metabolism and lipid biosynthesis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ACSL6 protein, researchers can accurately detect and analyze its expression in various cell types, making it an ideal choice for studies in lipid metabolism, energy regulation, and metabolic disorders.
ACSL6 plays a crucial role in lipid metabolism by catalyzing the activation of long-chain fatty acids for various cellular processes, including energy production and membrane synthesis. Dysregulation of ACSL6 activity has been linked to metabolic disorders, such as obesity and insulin resistance, making it a potential therapeutic target for these conditions. Understanding the function of ACSL6 is essential for developing targeted interventions that could improve metabolic health and prevent associated diseases.
Product Name:
ACSL6 Rabbit Polyclonal Antibody
SKU:
CAB7965
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 383-622 of human ACSL6 (NP_001192180.1).
Endoplasmic reticulum membrane, Microsome membrane, Mitochondrion outer membrane, Peroxisome membrane, Single-pass type III membrane protein.
Calculated MW:
78kDa
Observed MW:
77kDa
The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
23305
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of Rat brain, using ACSL6 Rabbit pAb (CAB7965) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
