The ACSBG2 Antibody (PACO36122) is a polyclonal antibody designed for research involving ACSBG2, a key enzyme involved in lipid metabolism and fatty acid biosynthesis. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in a variety of research applications.ACSBG2, also known as acyl-CoA synthetase bubblegum family member 2, plays a crucial role in lipid metabolism by catalyzing the activation of long-chain fatty acids for energy production and lipid synthesis. Its dysregulation has been linked to various metabolic disorders, making it a potential target for therapeutic interventions.
This antibody is validated for use in Western blot applications, enabling researchers to detect and analyze ACSBG2 protein levels in different cell types and tissues. By studying the expression and function of ACSBG2, researchers can gain valuable insights into lipid metabolism, energy regulation, and metabolic disorders, paving the way for potential therapeutic strategies targeting ACSBG2 for the treatment of metabolic diseases.
Western blot. All lanes: ACSBG2 antibody at 4µg/ml. Lane 1: A431 whole cell lysate. Lane 2: K562 whole cell lysate. Lane 3: A549 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 75, 69, 54, 52 kDa. Observed band size: 52 kDa.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO36122 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human gastric cancer using PACO36122 at dilution of 1:100.
Background:
Mediates activation of long-chain fatty acid, for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acid,. Also able to activate very long-chain fatty acid, ; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid, May play a role in spermatogenesis.
Synonyms:
Long-chain-fatty-acid, -CoA ligase ACSBG2 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 2) (Bubblegum-related protein) (PRTD-NY3), ACSBG2, BGR
UniProt Protein Function:
ACSBG2: Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis. Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Mitochondrial; Hydrolase; Ligase; EC 6.2.1.3Chromosomal Location of Human Ortholog: 19p13.3Cellular Component: cytoplasm; cytosol; mitochondrionMolecular Function: acyl-CoA hydrolase activity; long-chain-fatty-acid-CoA ligase activity; very-long-chain-fatty-acid-CoA ligase activityBiological Process: fatty acid metabolic process
