The ACSBG2 Polyclonal Antibody (PAC013800) is specifically designed for research involving ACSBG2, an enzyme involved in lipid metabolism and fatty acid synthesis. This antibody, produced in rabbits, has a high level of reactivity with human samples and has been validated for use in Western blot applications. By binding to the ACSBG2 protein, this antibody allows for the detection and analysis of ACSBG2 in various cell types, making it ideal for studies in metabolism and cancer research.ACSBG2, also known as Acyl-CoA synthetase bubblegum family member 2, plays a crucial role in lipid biosynthesis and transport, making it a key player in cellular energy metabolism.
Dysregulation of ACSBG2 has been linked to various metabolic disorders, including obesity and fatty liver disease. By understanding the function of ACSBG2, researchers can gain insight into these diseases and potentially develop targeted therapies to treat them.Overall, the ACSBG2 Polyclonal Antibody is a valuable tool for researchers studying lipid metabolism, fatty acid synthesis, and metabolic disorders. Its high reactivity and specificity make it a reliable choice for Western blotting experiments aimed at understanding the role of ACSBG2 in health and disease.
Antibody Name:
ACSBG2 Antibody (PACO13800)
Antibody SKU:
PACO13800
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:500-1:5000, IHC:1:5-1:20
Species Reactivity:
Human
Immunogen:
Fusion protein of human ACSBG2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO13800(ACSBG2 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human stomach cancer tissue using PACO13800(ACSBG2 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Long-chain-fatty-acid, CoA ligase ACSBG2 is an enzyme that in humans is encoded by the ACSBG2 gene.Mediates activation of long-chain fatty acid, for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acid, . Also able to activate very long-chain fatty acid, , however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid, May play a role in spermatogenesis.
Synonyms:
acyl-CoA synthetase bubblegum family member 2
UniProt Protein Function:
ACSBG2: Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis. Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Mitochondrial; Hydrolase; Ligase; EC 6.2.1.3Chromosomal Location of Human Ortholog: 19p13.3Cellular Component: cytoplasm; cytosol; mitochondrionMolecular Function: acyl-CoA hydrolase activity; long-chain-fatty-acid-CoA ligase activity; very-long-chain-fatty-acid-CoA ligase activityBiological Process: fatty acid metabolic process
