The ACSBG2 Polyclonal Antibody (PAC013799) is a valuable tool for researchers studying ACSBG2, a key enzyme involved in lipid metabolism and fatty acid biosynthesis. This antibody, generated in rabbits, demonstrates high specificity and sensitivity in detecting ACSBG2 in human samples, making it an excellent choice for Western blot applications. By binding to the ACSBG2 protein, this antibody enables precise identification and analysis of ACSBG2 expression in a variety of cell types, making it an ideal tool for investigations in the fields of metabolism and lipid biology.
ACSBG2, also known as long-chain-fatty-acid-CoA ligase ACSBG2, plays a crucial role in lipid homeostasis by catalyzing the biosynthesis of fatty acids for energy production and storage. Dysregulation of ACSBG2 has been implicated in various metabolic disorders, making it a promising target for research into obesity, diabetes, and cardiovascular diseases. Understanding the function of ACSBG2 is essential for developing strategies to regulate lipid metabolism and combat associated diseases.
Antibody Name:
ACSBG2 Antibody (PACO13799)
Antibody SKU:
PACO13799
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:500-1:5000, IHC:1:5-1:20
Species Reactivity:
Human
Immunogen:
Fusion protein of human ACSBG2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human stomach cancer tissue using PACO13799(ACSBG2 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Long-chain-fatty-acid, CoA ligase ACSBG2 is an enzyme that in humans is encoded by the ACSBG2 gene.Mediates activation of long-chain fatty acid, for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acid, . Also able to activate very long-chain fatty acid, , however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid, May play a role in spermatogenesis.
Synonyms:
acyl-CoA synthetase bubblegum family member 2
UniProt Protein Function:
ACSBG2: Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis. Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Mitochondrial; Hydrolase; Ligase; EC 6.2.1.3Chromosomal Location of Human Ortholog: 19p13.3Cellular Component: cytoplasm; cytosol; mitochondrionMolecular Function: acyl-CoA hydrolase activity; long-chain-fatty-acid-CoA ligase activity; very-long-chain-fatty-acid-CoA ligase activityBiological Process: fatty acid metabolic process
