The ACPT Antibody (PAC018646) is a highly specific monoclonal antibody designed for research involving ACPT, a key enzyme involved in lipid metabolism and phospholipid biosynthesis. This antibody, generated in mice, exhibits strong reactivity with human samples and is validated for use in immunofluorescence and immunohistochemistry applications.ACPT, also known as acid phosphatase 1, is essential for the breakdown of phospholipids and plays a crucial role in maintaining cellular membrane integrity. Dysregulation of ACPT has been linked to lipid-related disorders, making it a promising target for therapeutic intervention.
By enabling precise detection and localization of ACPT in various biological samples, this antibody is an invaluable tool for studying lipid metabolism and lipid-related diseases.Researchers studying lipid biology, metabolic disorders, and lipid-related diseases such as atherosclerosis and metabolic syndrome will benefit from the specificity and sensitivity of the ACPT Antibody (PAC018646). Its ability to accurately detect ACPT expression and localization in tissues and cells makes it a reliable asset for understanding the mechanisms underlying lipid homeostasis and identifying potential therapeutic targets.
Antibody Name:
ACPT Antibody (PACO18646)
Antibody SKU:
PACO18646
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human ACPT
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO18646(ACPT Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18646(ACPT Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
acid, phosphatases are enzymes capable of hydrolyzing orthophosphoric acid, esters in an acid, medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid, phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Synonyms:
acid, phosphatase, testicular
UniProt Protein Function:
ACPT: Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage. Belongs to the histidine acid phosphatase family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Cofactor and Vitamin Metabolism - riboflavin; Phosphatase (non-protein); Membrane protein, integral; EC 3.1.3.2; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 19q13.4Cellular Component: integral to membraneMolecular Function: acid phosphatase activityBiological Process: dephosphorylation
UniProt Protein Details:
NCBI Summary:
Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
