The ACOT11 Polyclonal Antibody (PAC040030) is a valuable tool for researchers studying ACOT11, an enzyme involved in lipid metabolism and cellular energy regulation. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples and is validated for use in Western blot applications. By targeting the ACOT11 protein, this antibody enables precise detection and analysis in a variety of cell types, making it a versatile tool for studies in metabolism, lipid signaling, and related fields.ACOT11, also known as acyl-CoA thioesterase 11, plays a crucial role in breaking down fatty acids for energy production and lipid metabolism regulation.
Its involvement in cellular processes related to energy utilization and lipid storage makes it a key molecule of interest in understanding metabolic diseases such as obesity, diabetes, and cardiovascular disorders. Investigating the functions of ACOT11 can provide insights into the mechanisms underlying these conditions and may lead to the development of targeted therapies in the future.
Antibody Name:
ACOT11 Antibody (PACO40030)
Antibody SKU:
PACO40030
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human Acyl-coenzyme A thioesterase 11 protein (35-254AA)
ACOT11: Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Hydrolase; EC 3.1.2.-Chromosomal Location of Human Ortholog: 1p32.3Cellular Component: cytoplasmMolecular Function: acyl-CoA hydrolase activity; lipid bindingBiological Process: response to temperature stimulus; response to cold; fatty acid metabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
