The ACOT11 Polyclonal Antibody (PAC015262) is a high-quality antibody specifically designed for research involving the ACOT11 protein. ACOT11, also known as acyl-CoA thioesterase 11, plays a key role in lipid metabolism and has been implicated in various diseases, including metabolic disorders and cancer.This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. It binds specifically to the ACOT11 protein, allowing for accurate detection and analysis in a variety of cell types.
Researchers in the fields of metabolism, cancer biology, and lipid biology will find this antibody invaluable for their studies.Understanding the function and regulation of ACOT11 is crucial for unraveling its role in disease pathogenesis and identifying potential therapeutic targets. By using this antibody, researchers can gain valuable insights into the molecular mechanisms involving ACOT11 and its impact on cellular metabolism, providing valuable information for the development of novel treatments for metabolic disorders and cancer.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15262(ACOT11 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human liver cancer tissue, Human fetal kidney tissue, Primary antibody: PACO15262(ACOT11 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 90 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15262(ACOT11 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acid, to the corresponding non-esterified fatty acid, and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants.
Synonyms:
Acyl-CoA thioesterase 11
UniProt Protein Function:
ACOT11: Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Hydrolase; EC 3.1.2.-Chromosomal Location of Human Ortholog: 1p32.3Cellular Component: cytoplasmMolecular Function: acyl-CoA hydrolase activity; lipid bindingBiological Process: response to temperature stimulus; response to cold; fatty acid metabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
