The ACOT11 Polyclonal Antibody (PAC015261) is a valuable tool for researchers studying ACOT11, an enzyme involved in lipid metabolism and fatty acid oxidation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards ACOT11 in human samples, making it ideal for Western blotting applications. By targeting the ACOT11 protein, this antibody allows for precise detection and quantification, enabling in-depth analysis of ACOT11 expression in various cell types.ACOT11, also known as acyl-CoA thioesterase 11, plays a crucial role in lipid catabolism and energy production through fatty acid oxidation.
Dysregulation of ACOT11 has been linked to metabolic disorders and diseases such as obesity and diabetes, making it a key target for research in the field of metabolism and energy homeostasis. By understanding the function and regulation of ACOT11, researchers can uncover potential therapeutic strategies for treating metabolic disorders and related conditions.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15261(ACOT11 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal kidney tissue, Human fetal lung tissue, Primary antibody: PACO15261(ACOT11 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 90 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15261(ACOT11 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acid, to the corresponding non-esterified fatty acid, and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants.
Synonyms:
Acyl-CoA thioesterase 11
UniProt Protein Function:
ACOT11: Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Hydrolase; EC 3.1.2.-Chromosomal Location of Human Ortholog: 1p32.3Cellular Component: cytoplasmMolecular Function: acyl-CoA hydrolase activity; lipid bindingBiological Process: response to temperature stimulus; response to cold; fatty acid metabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
