The ACOD1 Polyclonal Antibody (PAC045950) is a powerful tool for researchers studying ACOD1, an enzyme involved in regulating inflammation and oxidative stress. This antibody, produced in rabbits, shows high specificity for human samples and has been validated for use in Western blotting applications. By targeting the ACOD1 protein, this antibody allows for accurate detection and analysis in various cell types, making it an essential resource for studies in immunology and inflammatory diseases.ACOD1, also known as aconitate decarboxylase 1, plays a crucial role in modulating the immune response by regulating the production of inflammatory mediators and oxidative stress molecules.
Understanding the function of ACOD1 is vital for developing new therapeutic strategies for diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. The ACOD1 Polyclonal Antibody provides researchers with a reliable tool to investigate the role of ACOD1 in these disease processes and potentially discover new treatment options.
Antibody Name:
ACOD1 Antibody (PACO45950)
Antibody SKU:
PACO45950
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Cis-aconitate decarboxylase protein (57-257AA)
Immunohistochemistry of paraffin-embedded human glioma using PACO45950 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human appendix tissue using PACO45950 at dilution of 1:100.
Background:
Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid, production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.
