IREB1 Rabbit Polyclonal Antibody (CAB7867)
- SKU:
- CAB7867
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | IREB1 Rabbit Polyclonal Antibody |
SKU: | CAB7867 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human Aconitase 1 (ACO1) (NP_002188.1). |
Sequence: | MSNP FAHL AEPL DPVQ PGKK FFNL NKLE DSRY GRLP FSIR VLLE AAIR NCDE FLVK KQDI ENIL HWNV TQHK NIEV PFKP ARVI LQDF TGVP AVVD FAAM RDAV KKLG GDPE KINP VCPA DLVI DHSI QVDF NRRA DSLQ KNQD LEFE RNRE RFEF LKWG SQAF HNMR II |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | IRP1; ACONS; HEL60; IREB1; IREBP; IREBP1; Aconitase 1 (ACO1) |
Positive Sample: | HCT116,Mouse kidney,Rat heart,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 98kDa |
Observed MW: | 98kDa |
The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants
Purification Method: | Affinity purification |
Gene ID: | 48 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |