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ACKR4 Antibody (PACO00544)

SKU:
PACO00544
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269

Description

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ACKR4 Antibody (PACO00544)

The ACKR4 Polyclonal Antibody (PACO00544) is a vital tool for researchers studying ACKR4, a chemokine receptor with a unique role in regulating the immune response. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is suitable for Western blot applications. By binding to ACKR4, the antibody facilitates the detection and analysis of this protein in various cell types, making it an excellent choice for investigations in immunology and cancer research.ACKR4, also known as CCRL1, is a key player in immune regulation, functioning as a scavenger receptor for chemokines.

Its role in modulating chemokine signaling pathways makes it a promising target for research on various diseases, including cancer, autoimmune conditions, and inflammatory disorders. Unraveling the mechanisms by which ACKR4 influences immune responses is essential for the development of novel therapeutic strategies aimed at manipulating immune function in disease settings.

Antibody Name:ACKR4 Antibody
Antibody SKU:PACO00544
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IF
Recommended Dilutions:WB:1:500-1:2000, IF:1:200-1:1000
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from the C-terminal region of human CCRL1.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:CCRL1; CCBP2; CCR11; VSHK1; C-C chemokine receptor type 11; C-C CKR-11; CC-CKR-11; CCR-11; CC chemokine receptor-like 1; CCRL1; CCX CKR
UniProt Protein Function:CCRL1: Receptor for CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:Membrane protein, integral; GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3q22

Cellular Component: early endosome; integral to plasma membrane; plasma membrane; recycling endosome

Molecular Function:chemokine binding; chemokine receptor activity; protein binding; scavenger receptor activity

Biological Process: chemotaxis; G-protein coupled receptor protein signaling pathway; immune response; receptor-mediated endocytosis

NCBI Summary:The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013]
UniProt Code:Q9NPB9
NCBI GenInfo Identifier:14285406
NCBI Gene ID:51554
NCBI Accession:Q9NPB9.1
UniProt Secondary Accession:Q9NPB9,B2R9U7,
UniProt Related Accession:Q9NPB9
Molecular Weight:
NCBI Full Name:Atypical chemokine receptor 4
NCBI Synonym Full Names:atypical chemokine receptor 4
NCBI Official Symbol:ACKR4  
NCBI Official Synonym Symbols:PPR1; CCBP2; CCR10; CCR11; CCRL1; VSHK1; CCR-11; CKR-11; CCX CKR; CCX-CKR; CC-CKR-11  
NCBI Protein Information:atypical chemokine receptor 4
UniProt Protein Name:Atypical chemokine receptor 4
UniProt Synonym Protein Names:C-C chemokine receptor type 11; C-C CKR-11; CC-CKR-11; CCR-11; CC chemokine receptor-like 1; CCRL1; CCX CKR
UniProt Gene Name:ACKR4  
UniProt Entry Name:ACKR4_HUMAN

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