The ACKR3 Polyclonal Antibody (CAB12712) is a powerful tool for researchers studying ACKR3, a chemokine receptor involved in immune response and inflammation regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the ACKR3 protein, this antibody enables precise detection and analysis of this important molecule in various cell types, making it well-suited for studies in immunology and cancer research.
ACKR3, also known as CXCR7, is a key player in modulating immune responses by regulating the chemotaxis of immune cells and influencing the inflammatory environment. Its involvement in immune regulation highlights its potential as a therapeutic target for conditions such as cancer, inflammatory diseases, and autoimmune disorders. Understanding the function of ACKR3 is essential for the development of novel treatments that target immune pathways involved in these diseases.
Product Name:
ACKR3 Rabbit Polyclonal Antibody
SKU:
CAB12712
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human ACKR3 (NP_064707.1).
This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas.
Purification Method:
Affinity purification
Gene ID:
57007
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ACKR3 Rabbit pAb (CAB12712) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
