The ACKR2 Polyclonal Antibody (PACO03425) is a valuable tool for researchers studying ACKR2, a chemokine receptor involved in immune regulation and inflammatory responses. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications including Western blotting.ACKR2, also known as atypical chemokine receptor 2, functions as a scavenger receptor for chemokines, helping to regulate the immune response and control inflammation. Its role in modulating chemokine signaling makes it a promising target for research in immunology and inflammatory diseases such as cancer, autoimmune disorders, and inflammatory conditions.
By utilizing the ACKR2 Polyclonal Antibody, researchers can detect and analyze ACKR2 expression in different cell types, providing valuable insights into its function and potential therapeutic applications. Understanding the mechanisms by which ACKR2 influences immune responses is crucial for developing targeted therapies and treatment strategies for various immune-related disorders.
Antibody Name:
ACKR2 Antibody
Antibody SKU:
PACO03425
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
IF:1:200-1:1000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the C-terminal region of human Chemokine Receptor D6.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CCBP2; CCR10; CMKBR9; Chemokine-binding protein 2; C-C chemokine receptor D6; Chemokine receptor CCR-10; Chemokine receptor CCR-9; Chemokine-binding protein D6
UniProt Protein Function:
CCBP2: Receptor for C-C type chemokines including SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-passChromosomal Location of Human Ortholog: 3p21.3Cellular Component: recycling endosome; integral to plasma membrane; early endosome; plasma membrane; actin filamentMolecular Function: C-C chemokine receptor activity; chemokine receptor activity; C-C chemokine binding; scavenger receptor activity; C-X-C chemokine receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; receptor-mediated endocytosis; neutrophil activation; multicellular organismal development; immune response; chemotaxis; inflammatory response
UniProt Protein Details:
NCBI Summary:
This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]
