ASAH1 Rabbit Polyclonal Antibody (CAB6527)
- SKU:
- CAB6527
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | ASAH1 Rabbit Polyclonal Antibody |
SKU: | CAB6527 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 140-389 of human ASAH1 (NP_001120977.1). |
Sequence: | IVAE DKKG HLIH GRNM DFGV FLGW NINN DTWV ITEQ LKPL TVNL DFQR NNKT VFKA SSFA GYVG MLTG FKPG LFSL TLNE RFSI NGGY LGIL EWIL GKKD VMWI GFLT RTVL ENST SYEE AKNL LTKT KILA PAYF ILGG NQSG EGCV ITRD RKES LDVY ELDA KQGR WYVV QTNY DRWK HPFF LDDR RTPA KMCL NRTS QENI SFET MYDV LSTK PVLN KLTV YTTL IDVT KGQF ETYL RDCP DPCI GW |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | AC; PHP; ASAH; PHP32; ACDase; SMAPME; ASAH1 |
Positive Sample: | Mouse kidney,Mouse heart,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Lysosome. |
Calculated MW: | 45kDa |
Observed MW: | 50kDa |
This gene encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. Processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid. This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene are associated with the lysosomal storage disorder, Farber lipogranulomatosis, and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy.
Purification Method: | Affinity purification |
Gene ID: | 427 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |