The Exportin 1 Polyclonal Antibody (CAB0299) is a valuable tool for researchers studying cellular transport processes. Exportin 1, also known as XPO1, is a protein involved in nuclear export of various molecules, including proteins and RNA. This antibody, developed through rabbit immunization, specifically targets Exportin 1 in human samples, allowing for efficient detection and analysis in Western blot experiments.Exportin 1 plays a crucial role in the regulation of gene expression and cellular signaling by controlling the transport of macromolecules between the nucleus and cytoplasm. Dysregulation of Exportin 1 has been linked to various diseases, including cancer, making it a promising target for therapeutic intervention.
By utilizing the Exportin 1 Polyclonal Antibody, researchers can deepen their understanding of the molecular mechanisms underlying disease progression and potentially identify new strategies for treatment.Overall, the Exportin 1 Polyclonal Antibody (CAB0299) offers a reliable and specific tool for investigating the role of Exportin 1 in cellular function and disease pathogenesis. Its high reactivity with human samples, coupled with its validated performance in Western blot assays, makes it an essential component of any research project focused on nuclear export processes.
Product Name:
CRM1/XPO1 Rabbit Polyclonal Antibody
SKU:
CAB0299
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 964-1064 of human CRM1/CRM1/XPO1 (NP_003391.1).
This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.
Purification Method:
Affinity purification
Gene ID:
7514
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CRM1/XPO1 antibody (CAB0299) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
