Acetyl-RELA (K218) Antibody (PACO06064)
- SKU:
- PACO06064
- Product Type:
- Antibody
- Target:
- RELA
- Reactivity:
- Human,Mouse,Rat
- Host Species:
- Rabbit
Frequently bought together:
Description
Acetyl-RELA (K218) Antibody (PACO06064)
The Acetyl-RelA (K218) Antibody (PACO06064) is a vital tool for researchers studying the acetylation of the RelA protein, a key regulator of inflammatory responses and immune signaling pathways. This polyclonal antibody, produced in-house using high-quality materials, specifically targets the acetylated form of RelA and has been rigorously validated for use in various experimental techniques, including Western blotting and immunofluorescence.RelA, also known as p65, is a subunit of the NF-kB transcription factor complex and plays a crucial role in regulating genes involved in immunity, inflammation, and cell survival. The acetylation of RelA modulates its activity and influences the expression of target genes, highlighting its importance in controlling immune responses and inflammatory processes.
By targeting the acetylated form of RelA, researchers can gain valuable insights into the molecular mechanisms underlying immune regulation and potentially identify new therapeutic targets for diseases characterized by dysregulated immune responses.This Acetyl-RelA (K218) Antibody is recommended for use in studies related to inflammation, cancer, autoimmune disorders, and other conditions where immune dysregulation plays a significant role. Its high specificity and sensitivity make it an essential tool for researchers seeking to understand the complex interplay between acetylation, immune signaling, and disease pathogenesis. Unlock the potential of your research with the Acetyl-RelA (K218) Antibody from AssayGenie.
| Product Name: | Acetyl-RELA (K218) Antibody | ||||||
| SKU: | PACO06064 | ||||||
| Size: | 50μg, 100μg | ||||||
| Uniprot No: | Q04206 | ||||||
| Target Names: | RELA | ||||||
| Alternative Names: | Avian reticuloendotheliosis viral (v rel) oncogene homolog A antibody; MGC131774 antibody; NF kappa B p65delta3 antibody; nfkappabp65 antibody; NFkB p65 antibody; NFKB3 antibody; Nuclear factor kappaB antibody; Nuclear Factor NF Kappa B p65 Subunit antibody; Nuclear factor NF-kappa-B p65 subunit antibody; Nuclear factor of kappa light polypeptide gene enhancer in B cells 3 antibody; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 antibody; OTTHUMP00000233473 antibody; OTTHUMP00000233474 antibody; OTTHUMP00000233475 antibody; OTTHUMP00000233476 antibody; OTTHUMP00000233900 antibody; p65 antibody; p65 NF kappaB antibody; p65 NFkB antibody; relA antibody; TF65_HUMAN antibody; Transcription factor NFKB3 antibody; Transcription factor p65 antibody; v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)) antibody; V rel avian reticuloendotheliosis viral oncogene homolog A antibody; v rel reticuloendotheliosis viral oncogene homolog A (avian) antibody; V rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B cells 3, p65 antibody | ||||||
| Raised in: | Rabbit | ||||||
| Species Reactivity: | Human, Mouse, Rat | ||||||
| Immunogen: | Synthesized peptide derived from the Human NFκB-p65 around the acetylation site of K218. | ||||||
| Immunogen Species: | Homo sapiens (Human) | ||||||
| Conjugate: | Non-conjugated | ||||||
| Isotype: | IgG | ||||||
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | ||||||
| Concentration: | It differs from different batches. Please contact us to confirm it. | ||||||
| Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. | ||||||
| Form: | Liquid | ||||||
| Tested Applications: | WB ELISA | ||||||
| Recommended Dilution: |
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| Storage: | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||
| Lead Time: | Basically, we can dispatch the products out in 7-10 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
| Function: | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Beside its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells. The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection. |
| Gene References into Functions: |
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| Involvement in disease: | A chromosomal aberration involving C11orf95 is found in more than two-thirds of supratentorial ependymomas. Translocation with C11orf95 produces a C11orf95-RELA fusion protein. C11orf95-RELA translocations are potent oncogenes that probably transform neural stem cells by driving an aberrant NF-kappa-B transcription program (PubMed:24553141). |
| Subcellular Location: | Nucleus. Cytoplasm. |
| Database Links: | HGNC: 9955 OMIM: 164014 KEGG: hsa:5970 STRING: 9606.ENSP00000384273 UniGene: Hs.502875 |
 | Western Blot analysis of MOUSE-BRAIN cells using Acetyl-NFκB-p65 (K218) Polyclonal Antibody. |
 | Western Blot analysis of JurkatK562 cells using Acetyl-NFκB-p65 (K218) Polyclonal Antibody. |
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