The Acetyl-p53 (K382) Polyclonal Antibody (CAB18663) is designed for research involving the acetylation of the p53 protein at lysine 382, a critical post-translational modification that regulates p53's activity in multiple cellular processes. The antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting acetylated p53 in human samples, and has been validated for use in Western blot applications.Acetylation of p53 at lysine 382 plays a key role in modulating p53's transcriptional activity, DNA binding ability, and stability, influencing its function as a tumor suppressor. This antibody enables researchers to investigate the role of acetylated p53 in various cellular contexts, offering valuable insights into the mechanisms underlying p53-mediated pathways in cancer development and progression.
With its specificity for acetylated p53 at lysine 382, this antibody is a valuable tool for studies in cancer biology, cell signaling, and epigenetic regulation. By elucidating the impact of p53 acetylation on cellular processes, researchers can uncover novel therapeutic targets and strategies for the treatment of cancers and other diseases involving dysregulated p53 signaling pathways.
Product Name:
Acetyl-p53-K382 Polyclonal Antibody
SKU:
CAB18663
Size:
20uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic acetylated peptide around K382 of human p53 (NP_000537.3).
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).
Purification Method:
Affinity purification
Gene ID:
7157
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Dot-blot analysis of all sorts of peptides using Acetyl-p53-K382 antibody (CAB18663) at 1:1000 dilution.
