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Acetyl-KRT (K194) Antibody (PACO00070)

SKU:
PACO00070
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
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Description

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Acetyl-KRT (K194) Antibody (PACO00070)

The Acetyl-KRT-K194 Polyclonal Antibody (PACO00070) is a valuable tool for researchers studying acetyl-KRT-K194, a key post-translational modification involved in various cellular processes. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to acetyl-KRT-K194, this antibody enables precise detection and analysis of this modified protein in diverse cell types, making it ideal for investigations in the fields of cell biology and molecular biology.

Acetyl-KRT-K194 is known to play a crucial role in regulating cell signaling pathways, gene expression, and protein function. Understanding the impact of this modification on cellular processes is essential for unraveling its involvement in various physiological and pathological conditions. The Acetyl-KRT-K194 Polyclonal Antibody provides researchers with a reliable tool for exploring the function and significance of acetyl-KRT-K194, paving the way for advances in research on diseases such as cancer, neurodegenerative disorders, and metabolic syndromes.

Antibody Name:Acetyl-KRT (K194) Antibody
Antibody SKU:PACO00070
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from human Cytokeratin around the acetylation site of K194.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:KRT2; KRT2A; KRT2E; Keratin, type II cytoskeletal 2 epidermal; Cytokeratin-2e; CK-2e; Epithelial keratin-2e; Keratin-2 epidermis; Keratin-2e; K2e; Type-II keratin Kb2; KRT76; KRT2B; KRT2P; Keratin, type II cytoskeletal 2 oral; Cytokeratin-2P
UniProt Protein Function:K2: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K.
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: cornified envelope; cytosol; extracellular space; intermediate filament; membrane; nucleus

Molecular Function:protein binding; structural constituent of cytoskeleton; structural constituent of epidermis

Biological Process: epidermis development; keratinization; keratinocyte activation; keratinocyte migration; keratinocyte proliferation; peptide cross-linking

Disease: Ichthyosis, Bullous Type

NCBI Summary:The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
UniProt Code:P35908
NCBI GenInfo Identifier:239938650
NCBI Gene ID:3849
NCBI Accession:P35908.2
UniProt Secondary Accession:P35908,Q4VAQ2,
UniProt Related Accession:P35908
Molecular Weight:65kDa
NCBI Full Name:Keratin, type II cytoskeletal 2 epidermal
NCBI Synonym Full Names:keratin 2
NCBI Official Symbol:KRT2  
NCBI Official Synonym Symbols:K2e; KRTE; CK-2e; KRT2A; KRT2E  
NCBI Protein Information:keratin, type II cytoskeletal 2 epidermal
UniProt Protein Name:Keratin, type II cytoskeletal 2 epidermal
UniProt Synonym Protein Names:Cytokeratin-2e; CK-2e; Epithelial keratin-2e; Keratin-2 epidermis; Keratin-2e; K2e; Type-II keratin Kb2
Protein Family:Keratin
UniProt Gene Name:KRT2  

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