Acetyl-HNF4A/HNF4G (Lys127/79) Antibody (PACO07331)
- SKU:
- PACO07331
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Acetyl-HNF4A/HNF4G (Lys127/79) Antibody (PACO07331)
The Acetyl-HNF4A/HNF4G Lys127/79 Antibody (PACO07331) is a highly specific tool for researchers studying the acetylation of HNF4A and HNF4G proteins, both of which are transcription factors critical for the regulation of gene expression in the liver and other tissues. This antibody, generated in rabbits, is validated for use in multiple applications, including Western blot and immunoprecipitation, allowing for the detection and analysis of acetylated HNF4A and HNF4G proteins in various cell types.HNF4A and HNF4G are key players in maintaining metabolic homeostasis and are involved in various physiological processes, including glucose and lipid metabolism.
The acetylation of these proteins can impact their transcriptional activity, thus affecting gene expression patterns and metabolic pathways. By utilizing the Acetyl-HNF4A/HNF4G Lys127/79 Antibody in their research, scientists can gain insights into the regulatory mechanisms involving these proteins and their roles in metabolic disorders, such as diabetes and fatty liver disease.Overall, this antibody serves as a valuable tool for researchers interested in elucidating the complex roles of HNF4A and HNF4G in gene regulation and metabolic pathways, offering new avenues for therapeutic interventions targeting metabolic disorders.
| Antibody Name: | Acetyl-HNF4A/HNF4G (Lys127/79) Antibody (PACO07331) |
| Antibody SKU: | PACO07331 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:10000-1:20000, WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic Acetyl peptide from human protein at AA range: 127(HNF-4 α )/79(HNF-4 γ ) |
| Form: | Liquid |
| Storage Buffer: | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of mouse-lung mouse-brain mouse-heart Hela mouse-liver lysate, antibody was diluted at 500. Secondary antibody was diluted at 1:20000. |
| Synonyms: | Hepatocyte nuclear factor 4-α (HNF-4-α) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) Hepatocyte nuclear factor 4-γ (HNF-4-γ) (Nuclear receptor subfamily 2 group A member 2)(TCF-14) (Transcription factor HNF-4) |
| UniProt Protein Function: | HNF4 alpha: a nuclear transcription factor which binds DNA as a homodimer. Controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic gene, alpha 1-antitrypsin, apolipoprotein CIII, and transthyretin genes. May be essential for development of the liver, kidney and intestine. Mutations have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Four alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Nuclear receptor; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 20q13.12 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:RNA polymerase II transcription factor activity, enhancer binding; ligand-dependent nuclear receptor activity; protein binding; protein homodimerization activity; DNA binding; zinc ion binding; steroid hormone receptor activity; transcription factor activity; fatty acid binding; receptor binding Biological Process: transcription initiation from RNA polymerase II promoter; regulation of lipid metabolic process; intracellular receptor-mediated signaling pathway; positive regulation of transcription, DNA-dependent; lipid homeostasis; glucose homeostasis; endocrine pancreas development; regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; xenobiotic metabolic process; regulation of gastrulation; response to glucose stimulus; ornithine metabolic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; lipid metabolic process; negative regulation of cell growth; blood coagulation; regulation of insulin secretion; sex differentiation; phospholipid homeostasis Disease: Fanconi Renotubular Syndrome 4 With Maturity-onset Diabetes Of The Young; Maturity-onset Diabetes Of The Young, Type 1; Diabetes Mellitus, Noninsulin-dependent |
| NCBI Summary: | The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012] |
| UniProt Code: | P41235 |
| NCBI GenInfo Identifier: | 148886624 |
| NCBI Gene ID: | 3172 |
| NCBI Accession: | P41235.3 |
| UniProt Secondary Accession: | P41235,O00659, O00723, Q14540, Q5QPB8, Q6B4V5, Q6B4V6 Q6B4V7, Q92653, Q92654, A5JW41, B2RPP8, |
| UniProt Related Accession: | P41235 |
| Molecular Weight: | |
| NCBI Full Name: | Hepatocyte nuclear factor 4-alpha |
| NCBI Synonym Full Names: | hepatocyte nuclear factor 4, alpha |
| NCBI Official Symbol: | HNF4AÂ Â |
| NCBI Official Synonym Symbols: | TCF; HNF4; MODY; FRTS4; MODY1; NR2A1; TCF14; HNF4a7; HNF4a8; HNF4a9; NR2A21; HNF4alpha  |
| NCBI Protein Information: | hepatocyte nuclear factor 4-alpha; TCF-14; HNF4alpha10/11/12; transcription factor 14; transcription factor HNF-4; hepatic nuclear factor 4 alpha; nuclear receptor subfamily 2 group A member 1 |
| UniProt Protein Name: | Hepatocyte nuclear factor 4-alpha |
| UniProt Synonym Protein Names: | Nuclear receptor subfamily 2 group A member 1; Transcription factor 14; TCF-14; Transcription factor HNF-4 |
| Protein Family: | Hepatocyte nuclear factor |
| UniProt Gene Name: | HNF4AÂ Â |
| UniProt Entry Name: | HNF4A_HUMAN |
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