The Acetyl-Histone H2B Lys12 Polyclonal Antibody (PACO00159) is a valuable tool for researchers studying epigenetics and chromatin modifications. This antibody, produced in rabbits, specifically targets acetylated histone H2B at lysine 12, a post-translational modification associated with gene activation and transcriptional regulation.With its high reactivity towards human samples, this antibody is ideal for use in Western blot applications to detect and analyze acetyl-histone H2B lys12 in various cell types. By targeting this specific histone modification, researchers can gain insights into the regulation of gene expression and potentially uncover new mechanisms underlying diseases such as cancer and developmental disorders.
The acetylation of histone proteins is a crucial epigenetic modification that plays a key role in chromatin structure and gene regulation. Understanding the role of acetyl-histone H2B lys12 can provide valuable insights into the complex mechanisms of gene activation and repression, as well as potential therapeutic targets for diseases related to abnormal gene expression patterns. Researchers in the fields of epigenetics, cancer biology, and developmental biology can greatly benefit from the use of this antibody in their studies.
Antibody Name:
Acetyl-Histone H2B (Lys12) Antibody
Antibody SKU:
PACO00159
Size:
50ug
Host Species:
Rabbit
Tested Applications:
WB
Recommended Dilutions:
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthetic Peptide
Form:
Liquid
Storage Buffer:
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
H2B1A: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Transcribed exclusively in testis, and the corresponding protein is also present in mature sperm. Belongs to the histone H2B family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 6p22.2Cellular Component: extrinsic to plasma membrane; nuclear chromosome, telomeric region; nucleoplasm; nucleosome; nucleusMolecular Function: DNA binding; protein heterodimerization activityBiological Process: establishment and/or maintenance of chromatin architecture; inflammatory response; nucleosome assembly; nucleosome disassembly; plasminogen activation; positive regulation of binding; spermatogenesis, exchange of chromosomal proteins
UniProt Protein Details:
NCBI Summary:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
