The Acetyl-histone H2B (K5) Antibody (PACO06047) is a polyclonal antibody specifically designed for research involving the acetylation of histone H2B at lysine 5 (K5). This modification plays a crucial role in gene expression regulation and chromatin remodeling, making this antibody an essential tool for studying epigenetics and transcriptional regulation.Raised in rabbits, this antibody is highly reactive with human samples and has been validated for use in various applications, including Western blotting and immunohistochemistry. By binding to the acetylated histone H2B at K5, researchers can accurately detect and analyze the levels of this modification in different cell types and tissues, providing valuable insights into the epigenetic regulation of gene expression.
The acetylation of histone H2B at K5 has been linked to various biological processes, including DNA damage repair, cell proliferation, and differentiation. Dysregulation of this modification has been associated with diseases such as cancer, neurodegenerative disorders, and autoimmune conditions, making it a promising target for therapeutic interventions.By using the Acetyl-histone H2B (K5) Antibody (PACO06047), researchers can deepen their understanding of epigenetic mechanisms and explore potential therapeutic strategies for diseases influenced by histone acetylation. This antibody is a valuable tool for studies in the fields of molecular biology, cancer research, and epigenetics,
Synthesized peptide derived from human Histone H2B around the acetylation site of K5.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of VEC cells using Acetyl-Histone H2B (K5) Polyclonal Antibody.
Western Blot analysis of 3T3 cells using Acetyl-Histone H2B (K5) Polyclonal Antibody.
Synonyms:
H2BFS; Histone H2B type F-S; Histone H2B.s; H2B/s
UniProt Protein Function:
H2BFS: a core component of the nucleoosome. The nucleosome, a basic organizational unit of chromosomal DNA, is octrameric, consisting of two molecules each of histones H2B, H2A, H3, H4. The octamer wraps approximately 147 bp of DNA. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 21q22.3Cellular Component: cytoplasm; extracellular space; nucleoplasm; nucleusMolecular Function: DNA binding; protein heterodimerization activityBiological Process: antibacterial humoral response; defense response to Gram-positive bacterium; innate immune response in mucosa; nucleosome assembly; substantia nigra development
