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Acetyl-Histone H2A (Lys5) Antibody (PACO00155)

SKU:
PACO00155
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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Acetyl-Histone H2A (Lys5) Antibody (PACO00155)

The Acetyl-Histone H2A Lys5 Polyclonal Antibody (PACO00155) is a valuable tool for researchers studying epigenetics and chromatin remodeling. This antibody, generated in rabbits, specifically targets the acetylated lysine 5 residue on histone H2A, a key histone modification associated with gene activation and transcriptional regulation.This antibody is highly specific to human samples and has been validated for use in techniques such as Western blotting and immunohistochemistry. Its ability to bind to acetylated histone H2A lysine 5 allows for the detection and analysis of this important epigenetic mark in a variety of cell types and experimental settings, making it an essential reagent for studies in cancer research, developmental biology, and epigenetics.

Histone acetylation plays a crucial role in the regulation of gene expression and cellular processes, and dysregulation of this process is implicated in various diseases, including cancer and neurological disorders. By targeting the acetylated lysine 5 residue on histone H2A, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.

Antibody Name:Acetyl-Histone H2A (Lys5) Antibody
Antibody SKU:PACO00155
Size:50ug
Host Species:Rabbit
Tested Applications:WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:synthetic Peptide
Form:Liquid
Storage Buffer:PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method:Affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:HIST1H2AG; H2AFP; HIST1H2AI; H2AFC; HIST1H2AK; H2AFD; HIST1H2AL; H2AFI; HIST1H2AM; H2AFN; Histone H2A type 1; H2A.1; Histone H2A/p; HIST2H2AA3; H2AFO; HIST2H2AA; HIST2H2AA4; Histone H2A type 2-A; Histone H2A.2; Histone H2A/o; HIST3H2A; Histone H2A type 3
UniProt Protein Function:H2A.1: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H2A family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 6p22.1

Cellular Component: nuclear chromatin; nucleus

Molecular Function:DNA binding; enzyme binding; protein binding

Biological Process: chromatin silencing

NCBI Summary:Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]
UniProt Code:P0C0S8
NCBI GenInfo Identifier:83288406
NCBI Gene ID:8969
NCBI Accession:P0C0S8.2
UniProt Secondary Accession:P0C0S8,P02261, Q2M1R2, Q76PA6,
UniProt Related Accession:P0C0S8
Molecular Weight:14kDa
NCBI Full Name:Histone H2A type 1
NCBI Synonym Full Names:histone cluster 1 H2A family member g
NCBI Official Symbol:HIST1H2AG  
NCBI Official Synonym Symbols:H2AG; H2A/p; H2AFP; H2A.1b; pH2A/f  
NCBI Protein Information:histone H2A type 1
UniProt Protein Name:Histone H2A type 1
UniProt Synonym Protein Names:Histone H2A/p
UniProt Gene Name:HIST1H2AG  

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