[KO Validated] Histone H2A.Z Rabbit Polyclonal Antibody (CAB12442)
- SKU:
- CAB12442
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | [KO Validated] Histone H2A.Z Rabbit Polyclonal Antibody |
SKU: | CAB12442 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-128 of human H2AFZ (NP_002097.1). |
Sequence: | MAGG KAGK DSGK AKTK AVSR SQRA GLQF PVGR IHRH LKSR TTSH GRVG ATAA VYSA AILE YLTA EVLE LAGN ASKD LKVK RITP RHLQ LAIR GDEE LDSL IKAT IAGG GVIP HIHK SLIG KKGQ QKTV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | H2AZ; H2A.z; H2A/z; H2AFZ; H2A.Z-1; .Z |
Positive Sample: | HL-60,MCF7,22Rv1,PC-12,HepG2,Mouse testis,Mouse thymus,293T |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus. |
Calculated MW: | 13kDa |
Observed MW: | 14kDa |
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.
Purification Method: | Affinity purification |
Gene ID: | 3015 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |