The FOXA1 Polyclonal Antibody (CAB15278) is a valuable tool for researchers studying FOXA1, a key transcription factor known for its role in regulating gene expression related to development, metabolism, and cancer. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the FOXA1 protein, this antibody enables precise detection and analysis of FOXA1 expression in various cell types, making it ideal for investigations in molecular biology and cancer research.
FOXA1, also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a crucial player in controlling gene expression programs involved in cell differentiation and tissue development. Its involvement in various cellular processes makes it a promising target for studies related to cancer progression, stem cell differentiation, and metabolic disorders. Understanding the mechanisms by which FOXA1 regulates gene expression is essential for uncovering its potential as a therapeutic target for diseases associated with dysregulated transcriptional control.
Product Name:
FOXA1 Rabbit Polyclonal Antibody
SKU:
CAB15278
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 263-472 of human FOXA1 (NP_004487.2).
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
Purification Method:
Affinity purification
Gene ID:
3169
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat testis, using FOXA1 Rabbit pAb (CAB15278) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
