The Acetyl-DNMT1 (K1127/K1129/K1131/K1133) Polyclonal Antibody (CAB5595) is a specialized research tool for studying the acetylation of DNA methyltransferase 1 (DNMT1) at specific lysine sites. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By targeting the acetyllysine residues on DNMT1, this antibody enables precise detection and analysis of post-translational modifications, providing valuable insights into epigenetic regulation processes.DNMT1 is a key enzyme involved in maintaining DNA methylation patterns during cell division, essential for proper gene expression and cellular function. The acetylation of DNMT1 at lysine residues has been linked to changes in its activity and stability, impacting epigenetic mechanisms that control gene silencing and activation.
Research on DNMT1 acetylation is crucial for understanding its role in gene regulation, genome stability, and disease development, particularly in cancer and other epigenetic disorders.By utilizing the Acetyl-DNMT1 (K1127/K1129/K1131/K1133) Polyclonal Antibody, researchers can accurately investigate the acetylation status of DNMT1 in various cellular contexts. This antibody is a valuable tool for studies in epigenetics, cancer biology, and developmental biology, offering new avenues for exploring the complex interplay between DNA
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1786
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunofluorescence analysis of C6 cells using Acetyl-DNMT1-K1127/K1129/K1131/K1133 antibody (CAB5595) at dilution of 1:100. Blue: DAPI for nuclear staining.
