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ACE2 Rabbit Polyclonal Antibody (CAB12737)

SKU:
CAB12737
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • Immunology Antibodies 1 Anti-ACE2 Antibody CAB12737
  • Immunology Antibodies 1 Anti-ACE2 Antibody CAB12737
  • Immunology Antibodies 1 Anti-ACE2 Antibody CAB12737
  • Immunology Antibodies 1 Anti-ACE2 Antibody CAB12737
  • Immunology Antibodies 1 Anti-ACE2 Antibody CAB12737
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:ACE2 Rabbit Polyclonal Antibody
SKU:CAB12737
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 18-740 of human ACE2 (NP_068576.1).
Sequence:QSTI EEQA KTFL DKFN HEAE DLFY QSSL ASWN YNTN ITEE NVQN MNNA GDKW SAFL KEQS TLAQ MYPL QEIQ NLTV KLQL QALQ QNGS SVLS EDKS KRLN TILN TMST IYST GKVC NPDN PQEC LLLE PGLN EIMA NSLD YNER LWAW ESWR SEVG KQLR PLYE EYVV LKNE MARA NHYE DYGD YWRG DYEV NGVD GYDY SRGQ LIED VEHT FEEI KPLY EHLH AYVR AKLM NAYP SYIS PIGC LPAH LLGD MWGR FWTN LYSL TVPF GQKP NIDV TDAM VDQA WDAQ RIFK EAEK FFVS VGLP NMTQ GFWE NSML TDPG NVQK AVCH PTAW DLGK GDFR ILMC TKVT MDDF LTAH HEMG HIQY DMAY AAQP FLLR NGAN EGFH EAVG EIMS LSAA TPKH LKSI GLLS PDFQ EDNE TEIN FLLK QALT IVGT LPFT YMLE KWRW MVFK GEIP KDQW MKKW WEMK REIV GVVE PVPH DETY CDPA SLFH VSND YSFI RYYT RTLY QFQF QEAL CQAA KHEG PLHK CDIS NSTE AGQK LFNM LRLG KSEP WTLA LENV VGAK NMNV RPLL NYFE PLFT WLKD QNKN SFVG WSTD WSPY ADQS IKVR ISLK SALG DKAY EWND NEMY LFRS SVAY AMRQ YFLK VKNQ MILF GEED VRVA NLKP RISF NFFV TAPK NVSD IIPR TEVE KAIR MSRS RIND AFRL NDNS LEFL GIQP TLGP PNQP PVS
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:ACEH; ACE2
Positive Sample:SH-SY5Y,Mouse kidney
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Cytoplasm, Secreted, Single-pass type I membrane protein.
Calculated MW:92kDa
Observed MW:100kDa

The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible.

Purification Method:Affinity purification
Gene ID:59272
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using ACE2 Rabbit pAb (CAB12737) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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